American Urological Association - Liposarcoma


Home Education AUAUniversity Education Products & Resources Pathology for Urologists Paratesticular Tumors Liposarcoma


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  • Most common sarcoma of paratesticular tissue in adults (followed by leiomyosarcoma).
  • Bulky paratesticular/testicular mass with yellow fatty appearance.
  • Histology:
    • Most often lipoma-like or well-differentiated liposarcoma. (Identifiable neoplastic fat cells are abundant) (image A).
    • Contain lipoblasts (large multivacuolated cell with pleomorphic nuclei and the nucleus is indented by the vacoulations) (image B).
    • Rarely may undergo high-grade dedifferentiation to spindle cell morphology.
  • Has prolonged clinical course with recurrences in >50%.
  • No metastasis in well-differentiated tumors.