American Urological Association - Granuloma Inguinale (Donovanosis)
Granuloma Inguinale (Donovanosis)
- Agent: Calymmatobacterium granulomatis (human itch mite).
- Appearance: Gram-negative pleomorphic intracellular bacilli.
- Clinical: single or multiple small papules that coalesce to form ulcers which are non-tender, indurated, firm, and have abundant beefy-red granulation tissue at the base (image A).
- Transmission: only mildly contagious.
- Ulcers contain abundant granulation tissue with numerous large histiocytes containing the dark particulate inclusions (Donovan bodies) that are best seen on silver stain (image B).
- Diagnosis must be established by microscopy because the bacilli are not readily cultured.
- Treatment: antibiotics are usually curative, although relapse may occur if the antibiotics are discontinued too early.