American Urological Association - Peyronie's Disease
- Clinical: Affects men between 20-80 yrs; presents with painful erection accompanied by distortion, bending, or constriction of the erect penis; usually have palpable nodules or plaques on the dorsal surface of the erect penis.
- Fibrosis of the tunica albuginea which does not affect the corpora cavernosa.
- Fibrous tissue may look like simple fibrosis or may resemble fibromatosis (image A) & (image B).
- The fibrous plaques may become calcified or ossified (os penis).
- Early lesions demonstrate perivascular inflammation in the loose connective tissue between the tunica albuginea and the sinusoids of the corpora cavernosa.
- Prognosis and treatment:
- 30% resolve spontaneously; 40% progress; 30% remain stable.
- Treatment with surgical excision of plaques, radiotherapy, and steroid injections.