American Urological Association - Spermatocytic Seminoma
- Extremely rare; older patients than other GCT (mean 54 years).
- Does not arise from ITGCN and is not associated with cryptorchidism.
- Serum tumor markers (AFP, HCG and LDH) are not elevated.
- Higher chance for bilaterality (up to 9%).
- No race predilection in contrast to other GCT.
- Unlike other testicular GCTs, has no counterpart in female ovary.
- Gross: well circumscribed, multinodular, soft and mucoid or gelatinous mass.
- Composed of 3 cell types (Hallmark is polymorphism) (image A) & (image B).
- Small lymphocyte-like cells: (6-8 µm) with smudged, degenerated appearance and scant cytoplasm.
- Intermediate cells: (15-20 µm) with round nucleus and granular chromatin and modest cytoplasm.
- Giant cells: (50-100 µm) with one or more nuclei, and demonstrate filamentous or "spireme-type" chromatin.
- Vast majority with excellent prognosis; malignant behavior in <1%.